Hair follicle regeneration suppresses Ras-driven oncogenic growth
نویسندگان
چکیده
منابع مشابه
Wnt5a Suppresses β-catenin Signaling during Hair Follicle Regeneration
Hair follicles display periodic growth. Wnt signaling is a critical regulator for hair follicle regeneration. Previously, we reported that Wnt5a inhibits the telogen-to-anagen transition of hair follicles, but the mechanism by which this process occurs has not yet been reported. Here, we determined the expression patterns of Wnt signaling pathway molecules by quantitative reverse transcription ...
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Hair follicles have characteristic sizes corresponding to their cycle-specific stage. However, how the anagen hair follicle specifies its size remains elusive. Here, we showed that in response to prolonged ectopic Wnt10b-mediated β-catenin activation, regenerating anagen hair follicles grew larger in size. In particular, the hair bulb, dermal papilla and hair shaft became enlarged, while the fo...
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5 Paper in this licentiate thesis 7 Abbreviations 8 Introduction 9 The hair follicle 9 Hair follicle morphogenesis 10 Molecular regulation of the HF morphogenesis 12 The hair cycle 13 Catagen 14 Telogen 15 Anagen 15 LIM-homeodomain transcription factors 18 Lhx2 19 Aim 21 Results and discussion 22 Expression of Lhx2 during HF morphogenesis and postnatal cycling 22 Transgenic over-expression of L...
متن کاملEpithelial Wnt ligand secretion is required for adult hair follicle growth and regeneration
β-Catenin, a key transducer molecule of Wnt signaling, is required for adult hair follicle growth and regeneration. However, the cellular source of Wnt ligands required for Wnt/β-catenin activation during anagen induction is unknown. In this study, we genetically deleted Wntless (Wls), a gene required for Wnt ligand secretion by Wnt-producing cells, specifically in the hair follicle epithelium ...
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Introduction: Nowadays, cell therapy is the most advanced treatment of peripheral nerve injury. The aim of this study was to determine the effects of transplantation of hair follicle stem cells on the regeneration of the sciatic nerve injury in rats. Methods: The bulge region of the rat whisker was isolated and cultured. Morphological and biological features of the cultured bulge cells were ob...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2019
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201907178